Understanding the biology of wound healing

February 26, 2021

 

The wound healing process is something common that happens as a response of our immune system, however, some patient’s conditions can difficult this process, leading to chronic wounds. This problem not only decreases the quality of life as increases the costs of healthcare.

 

The Thomas Jefferson University, trying to predict which wounds will heal and which will become chronic wounds, analyzed the cells of discarded wound dressings. In previous studies they found that when neutrophils (the main contributors in our immune system for the healing process) stay longer around the wound than a normal healing process that can lead to a chronic wound.  So, if we have a higher number of neutrophils in the discarded wound dressings that means that we have a potential chronic wound, and that was exactly what they found in their research.

 

This technic revealed having the potential to identify in early stages if a wound will develop to a chronic wound or not, which can lead to more targeted treatments. Furthermore, is a non-invasive approach and can help understanding better the cellular composition changes as it heals or becomes a chronic wound.

 

This research is even more promising when we also analyze the genetic material inside the wound dressings, as they did in further studies, as it helps finding genetic markers that predict the healing process. In patients with conditions like diabetic foot ulcers this approach can be crucial to improve their quality of life.

 

Source:

Thomas Jefferson University. “A new approach to understanding the biology of wound healing.” ScienceDaily. ScienceDaily, 15 September 2020.<www.sciencedaily.com/releases/2020/09/200915152443.htm>.


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